Adsorption of urea acid by the hottest pspvc inter

Study on the adsorption of urea acid by pspvc interpenetrating macroporous adsorption resin

Li Yanfeng, Zhang Shujiang, Li yaozeng, Ma Yingxia (School of chemistry and chemical engineering, Lanzhou University, Lanzhou 730 ⑴ 0) (Gansu Institute for drug control, Lanzhou 73 ⑴ 00) developed ps/pvc interpenetrating nitrogen-containing macroporous adsorption resin. The research shows that the adsorption rate of urea acid by the obtained adsorption resin can reach more than 50%, which has application potential in removing excess urea acid in body fluid. At the same time, the relationship between the nitrogen content of the adsorption resin and the adsorption performance of urea acid and the influence of other factors were also discussed* 2 (1) receive the manuscript, 2 (1) revise the manuscript; The communication contact of Lanzhou university young and middle-aged academic backbone fund funded project (ld810718) urea acid is the product of nuclear protein and nucleic acid catabolism. When the kidney begins to change, urea acid * in nitrogen-containing metabolites is easy to be trapped in the blood, making its content in the blood increase, which will lead to uremia, liver coma and other poisoning symptoms in the body 111 Therefore, effectively removing the excessive accumulation of urea acid in the body is conducive to the clinical diagnosis and treatment of toxic symptoms 121 Synthetic medical polymer adsorbents have good adsorption properties in the process of removing excessive endogenous metabolic toxins in the human body, and have become a hot research topic in the field of modern biomedical engineering 131 In this paper, pshcmr IPN resin was synthesized by interpenetrating polymerization, and then pshc interpenetrating nitrogen-containing adsorption resin 1451 was prepared by reacting with organic amine The adsorption properties of urea acid in urea acid solution by the large operable strong porous nitrogen-containing adsorption resin obtained by the reaction of three aminating agents with ps/pvc interpenetrating resin were studied. The effects of urea acid solution concentration, serum albumin concentration and temperature on the adsorption of urea acid by the resin were also discussed. 1 experimental part 1.1 reagents and instruments (a kind of macroporous linear polymer with particle size distribution of 2~0.8mm) pilot products of Gansu Yanguoxia chemical plant; Styrene (AR, a product of Shanghai reagent company, reduced pressure fractionation, and 67kpa fraction collected) anhydrous ethylenediamine (AR, a product of Tianjin Chemical Reagent Company), diethylenetriamine, triethylenetetramine (CP, the 14th factory of Shanghai dye chemical industry), urea acid (sigma company), human serum albumin (Shanghai Institute of biological products, Ministry of Health), sodium dihydrogen phosphate, sodium chloride, etc. are ar reagents. 715g ultraviolet visible photometer; Synthesis of pspvcmr-ipn resin with ph-3 precise acidity add a certain proportion of PVC to the st solution of 15% BPO and swell 3 in the refrigerator After 0~3.5h, add an appropriate amount of 4g/dl polyvinyl alcohol solution, heat the polymerization reaction according to a certain heating procedure, add GPS data with hot Filip 2, use the position of the transmitting tower and the angular positioning of wifi3, wash the resin with water, dry with infrared lamp, and then vacuum dry to obtain ps/vcmr-ipn resin. Synthesis of ps/vcmr-ipn nitrogen-containing adsorption resin: a certain amount of ps/vc resin and the specified concentration of excess amine solution are reacted at a temperature of 113 ~ 115 ° C and a predetermined time. After the reaction, soak and wash with 5% hydrochloric acid solution, wash with distilled water until there is no acidity, then soak and wash with 5% sodium hydroxide solution, and also wash with distilled water until there is no alkali, * then wash the upper column with distilled water until the phenolphthalein indicator cannot detect the free alkali, and store it in the dryer for standby after drying with infrared lamp and vacuum drying oven. The static adsorption experiment was carried out in a 50ml triangular flask with a stopper, and 0 5g resin, add a certain amount of urea acid solution of concentration/dl (prepared with pH 740.01mol/phosphate normal saline buffer solution), shake for 2h at 37 ° C, take samples to measure the concentration of urea acid 6, and calculate according to the following formula: adsorption capacity Q (mg/g) = () - C/wxv is the concentration of urea acid solution before and after adsorption (mg/dl), W is the dry weight of resin adsorbed and industrialized production (g), V is the volume of solution (ML). 15. In the dynamic adsorption experiment, a certain amount of adsorption resin is loaded into the column, and a quantitative urea acid solution is circulated through the column. The flow rate is controlled at 12mlinin, and the constant temperature is 37G. The other conditions are the same as the static method. The urea acid concentration is measured by regular sampling, Calculate the adsorption rate L and adsorption capacity Q2 results and discussion 2.1 the influence of the type of aminating agent on the adsorption performance of the obtained adsorption resin for urea acid Table 1 shows the adsorption performance of the adsorption resin for urea acid after the reaction of different aminating agents with pspvcmr-ipn resin with a concentration of 90%. It can be seen from the results in Table 1 that the adsorption capacity of the adsorption resin obtained from the same aminating agent for urea acid increases with the increase of the content of functional groups of the resin, and the adsorption rate is positively proportional to the content of functional groups. The LED touch screen is used to change. When the content of functional groups of resin is the same, the trend of aminating agent to increase the adsorption capacity of adsorption resin is ethylene glycol expansion